Approximately 200 entries to scientific or medical topics of interest because of their ethical or moral implications. Intended primarily for laypersons and professionals in the United Kingdom, but also throughout the world. Each entry gives definition, discussion (1-several pages), cross references, references, and contributor's name. 1st ed., 1977.

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

This paper surveys attempts in the recent literature to offer a modal condition on knowledge as a way of resolving the problem of scepticism. In particular, safety-based and sensitivity-based theories of knowledge are considered in detail, along with the anti-sceptical prospects of an explicitly anti-luck epistemology.

The cries of Lamentations are desperate, wailing up from the darkest side of human existence. They will not be silenced. Lament harasses those who oppress and calls all to justice—even God.

This paper explores the prospects for safety-based theories of knowledge in the light of some recent objections.

Much of the recent debate regarding scepticism has focussed on a certain template sceptical argument and a rather restricted set of proposals concerning how one might deal with that argument. Throughout this debate the ‘Moorean’ response to scepticism is often cited as a paradigm example of how one should not respond to the sceptical argument, so conceived. As I argue in this paper, however, there are ways of resurrecting the Moorean response to the sceptic. In particular, I consider the prospects (...) for three such proposals in this regard: a classical epistemic internalist neo-Mooreanism, a classical epistemic externalist neo-Mooreanism, and a non-classical McDowellian epistemic internalist neo-Mooreanism, and maintain that the last two of these proposals (both of which make appeal to a disjunctivist account of perception, broadly conceived) merit further exploration. Indeed, I claim that a suitably qualified version of neo-Mooreanism would actually sit quite well with the general philosophical motivations behind other key anti-sceptical views and I argue that given this fact neo-Mooreanism is actually at a dialectical advantage relative to other views when it comes to dealing with the sceptical problem as it is typically conceived. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 41.3 (2003) 426-427 [Access article in PDF] Timothy Smiley, editor. Mathematics and Necessity: Essays in the History of Philosophy. New York: Oxford University Press, 2000. Pp. ix + 166. Cloth, $35.00.Mathematics and Necessity contains essays by M. F. Burnyeat, Ian Hacking, and Jonathan Bennett based on lectures given to the British Academy in 1998. All concern the history of the philosophical treatment of (...) mathematics, necessity, or both, although there is no single thread running through all three essays.Burnyeat focuses on Plato's understanding of mathematics in the Republic, making use of the Timeaus in particular to defend his interpretation. Plato claimed that in the ideal society mathematics should be studied for a full ten years, which many have thought excessive. To explain it, Burnyeat argues that the role of mathematics is pervasive: ethics and politics are mathematical, because in Plato's view mathematics is a constitutive part of ethical understanding. On Burnyeat's interpretation, goodness is part of the objective world, and mathematics is a science of values. The link between mathematics and goodness in the objective world is forged by the concord, harmony, and unity of proportions, which express the goodness of the Divine Craftsman's beneficent design. Proportions are both intrinsically good and the proper study of mathematics.Burnyeat explains why Plato thinks abstract kinematics (the pure non-sensible counterpart to astronomy) and abstract harmonics lead to knowledge of the good. Abstract kinematics concerns the "harmony of the spheres" described in the Republic. Drawing heavily on the Timeaus, Burnyeat argues that the circular motions of the spheres are motions in the intelligence of the world soul and that there are similar motions in human souls. The world soul and human souls are spatial and have circular motions (invisibility and intangibility make them incorporeal). Souls are the most important subject matter of abstract harmonics—the study of good proportions. A soul that understands the various mathematical disciplines and their relations takes on the harmony and hence goodness of the world soul. Such a soul serves as a model for organizing the social world, a model which properly trained rulers can use to shape a community. Burnyeat's well-argued essay is compelling and exciting. [End Page 427]Ian Hacking's views provide a great contrast to Burnyeat's Plato. Hacking conducts a phenomenological inquiry into why some philosophers have become obsessed by mathematics as a source of philosophical inspiration. He holds that mathematics concerns a relatively minor part of human culture and that the influence of mathematics on philosophy is pernicious; he even describes it as an infection.Hacking examines the views of six philosophers: Plato, Leibniz, Mill, Descartes, Lakatos, and Wittgenstein. Hacking's assessment of the six philosophers is at times disputable, but it is also interesting and stimulating, and serves his phenomenological inquiry.Hacking traces philosophy's infection by mathematics to two factors. A mathematical proof can be perspicuous; that is, a proof can be "grasped," which requires seeing directly why something must be true and being able to recapitulate it. A mathematical proof can also anticipate facts about the world. He thinks that these two factors affect us in two ways: they give us the idea of a priori knowledge, and they dazzle us into unreasoned conviction in proofs. One might respond that, setting aside the feeling proofs give us, we are still justified in being impressed by them. Hacking argues that much of what impresses is based on a misunderstanding of their nature, which he attempts to correct.According to Hacking, a mathematical demonstration involves shifts of meaning that analytically bind the proof and the theorem it establishes. They thereby mutually support each other and provide what he calls self-authentication. The correctness of the proof is supported by the "analytified" truth of the theorem and the theorem is considered true because proven.This bootstrapping feature of mathematical proofs supports Hacking's deflationary account of necessity. Hacking suggests that the "must" of logical necessity rests upon our unwillingness to accept empirical counter-examples to the... (shrink)

This is the third selection of major works on the Scottish Enlightenment and includes the same combination of hard-to-find and popular works as in the two previous collections. Contents: An Essay on the Natural Equality of Men [1793] William Lawrence Brown, New introduction by Dr. William Scott 308 pp An Enquiry into the Origin of Moral Virtue [1733] Archibald Campbell 586 pp The Philosophical Works [1765] William Dudgeon, New introduction by David Berman 300 pp Institutes of Moral Philosophy For (...) the use of Students in the College of Edinburgh [1769] Adam Ferguson 340 pp A Comparative view of the State and Faculties of Man with those of the Animal World [1774] John Gregory 426 pp An Apology for the Life and Writings of David Hume, Esq [1777] Samuel Jackson A Letter to Adam Smith, On the Life, Death and Philosophy of his friend David Hume Esq [1777] George Horne (Bishop of Norwich) 252 pp. (shrink)

The status of boundaries and borders, questions of global poverty and inequality, criteria for the legitimate uses of force, the value of international law, human rights, nationality, sovereignty, migration, territory, and citizenship: debates over these critical issues are central to contemporary understandings of world politics. Bringing together an interdisciplinary range of contributors, including historians, political theorists, lawyers, and international relations scholars, this is the first volume of its kind to explore the racial and imperial dimensions of normative debates over global (...) justice. (shrink)

A common criticism of the use of algorithms in criminal justice is that algorithms and their determinations are in some sense ‘opaque’—that is, difficult or impossible to understand, whether because of their complexity or because of intellectual property protections. Scholars have noted some key problems with opacity, including that opacity can mask unfair treatment and threaten public accountability. In this paper, we explore a different but related concern with algorithmic opacity, which centers on the role of public trust in grounding (...) the legitimacy of criminal justice institutions. We argue that algorithmic opacity threatens the trustworthiness of criminal justice institutions, which in turn threatens their legitimacy. We first offer an account of institutional trustworthiness before showing how opacity threatens to undermine an institution’s trustworthiness. We then explore how threats to trustworthiness affect institutional legitimacy. Finally, we offer some policy recommendations to mitigate the threat to trustworthiness posed by the opacity problem. (shrink)

In this paper, I do three things. First, I offer an overview of an anti- luck epistemology, as set out in my book, Epistemic Luck. Second, I attempt to meet some of the main criticisms that one might level against the key theses that I propose in this work. And finally, third, I sketch some of the ways in which the strategy of anti- luck epistemology can be developed in new directions.

Liberalism is a term employed in a dizzying variety of ways in political thought and social science. This essay challenges how the liberal tradition is typically understood. I start by delineating different types of response—prescriptive, comprehensive, explanatory—that are frequently conflated in answering the question “what is liberalism?” I then discuss assorted methodological strategies employed in the existing literature: after rejecting “stipulative” and “canonical” approaches, I outline a contextualist alternative. Liberalism, on this account, is best characterised as the sum of the (...) arguments that have been classified as liberal, and recognised as such by other self-proclaimed liberals, over time and space. In the remainder of the article, I present an historical analysis of shifts in the meaning of liberalism in Anglo-American political thought between 1850 and 1950, focusing in particular on how Locke came to be characterised as a liberal. I argue that the scope of the liberal traditionexpanded during the middle decades of the twentieth century, such that it came to be seen by many as the constitutive ideology of the West. This capacious understanding of liberalism was a product of the ideological wars fought against “totalitarianism” and assorted developments in the social sciences. Today we both inherit and inhabit it. (shrink)

The notion that eukaryotes are ancestrally sexual has been gaining attention. This idea comes in part from the discovery of sets of “meiosis‐specific genes” in the genomes of protists. The existence of these genes has persuaded many that these organisms may be engaging in sex, even though this has gone undetected. The involvement of sex in protists is supported by the view that asexual reproduction results in the accumulation of mutations that would inevitably result in the decline and extinction of (...) such lineages. It is argued that this phenomenon can be obviated by polyploidy and that the “meiosis‐specific genes” are used in other processes, including polyploidy control and homologous recombination, independent of meiosis. These phenomena account for the finding that these genes are expressed in cultures devoid of apparent cell fusion events. Hence, it is also proposed that asexual, and not sexual, reproduction is the ancestral condition. (shrink)

Clearing a Space for Human Action demonstrates how Karl Barth's concern for ethical description cannot be separated from his concern for a proper theological description of the God-human relationship. Early in his career, Barth attempted to describe human ethical agency in terms that respected the co-inherence of dogmatics and ethics, but in such a way that neither human nor divine agency suffered absorption into the other. This book's conclusion calls for a treatment of Barth's Dogmatics as a sustained theological ethical (...) ontology. Only then can we hope to understand Barth's treatment of the human and the Divine in other parts of the Dogmatics. (shrink)

In this article, I explore recent work on realist political theory and international politics. I discuss how scholarship on the topic emanates from two different fields—International Relations and political philosophy—and argue that there is a good case for greater engagement between them. I open by delineating various kinds of realism, showing that the term covers a wide variety of methodological and political approaches. In particular, I suggest, it is important to recognize the difference between liberal and radical approaches. The remainder (...) of the essay examines assorted examples of realist international political theorizing, work that ranges from attempts to rewrite the canon of 20th century political thought to contributions to the vibrant global justice debates. (shrink)

A certain construal of the Gettier problem is offered, according to which this problem concerns the task of identifying the anti-luck condition on knowledge. A methodology for approaching this construal of the Gettier problem—anti-luck epistemology—is set out, and the utility of such a methodology is demonstrated. It is argued that a range of superficially distinct cases which are meant to pose problems for anti-luck epistemology are in fact related in significant ways. It is claimed that with these cases properly understood, (...) anti-luck epistemology is able to offer a suitable diagnosis of them which doesn’t threaten the necessity of the anti-luck condition for knowledge. (shrink)

When this work was first published in 1960, it immediately filled a void in Kantian scholarship. It was the first study entirely devoted to Kant's _Critique of Practical Reason_ and by far the most substantial commentary on it ever written. This landmark in Western philosophical literature remains an indispensable aid to a complete understanding of Kant's philosophy for students and scholars alike. This _Critique_ is the only writing in which Kant weaves his thoughts on practical reason into a unified argument. (...) Lewis White Beck offers a classic examination of this argument and expertly places it in the context of Kant's philosophy and of the moral philosophy of the eighteenth century. (shrink)

The idea of a returning golden age is widely understood and commonly presented both as a staple of Augustan propaganda and as a pervasive aspiration of Augustan society. TheCarmen Saeculare—an official commission for a public festival—is presented as a means by which the regime proclaimed to an enthusiastic populace the imminent renascence of the golden race. The aim of this article is to draw attention both to thefailureof theCarmen Saeculareexplicitly to proclaim the renascence of the race, and to the critique (...) implicit in the poem of the very idea of a renascence. The golden race, according to this reading, might be undesirable on account of its very goldenness. The golden race was the subject of a complex myth at the centre of a complex discourse: neither the ‘official’ nor the popular response to the idea of its return can have been as simple as they are frequently portrayed. (shrink)

In this article I pursue two main lines of argument. First, I seek to delineate two distinctive modes of justifying imperialism found in nineteenth-century political thought (and beyond). The 'liberal civilizational'li model, articulated most prominently by John Stuart Mill, justified empire primarily in terms of the benefits that it brought to subject populations. Its proponents sought to 'civilize'lthe 'barbarian'. An alternative `republican' model focused instead on the benefits - glory, honour and power above all - that accrued to the imperial (...) state. Less concerned with spreading civilization, its proponents concentrated on fortifying the imperial polity. Second, I offer a 'republican' interpretation of the writings of the historian and public moralist J.A. Froude (1818-94), arguing that he both diagnosed the problems of modern Britain and prescribed imperial solutions to those problems, based on his reading of the fate of the Roman republic. (shrink)

(No abstract is available for this citation).

Support is canvassed for a new approach to epistemology called anti-risk epistemology. It is argued that this proposal is rooted in the motivations for an existing account, known as anti-luck epistemology, but is superior on a number of fronts. In particular, anti-risk epistemology is better placed than anti-luck epistemology to supply the motivation for certain theoretical moves with regard to safety-based approaches to knowledge. Moreover, anti-risk epistemology is more easily extendable to epistemological questions beyond that in play in the theory (...) of knowledge specifically. A key advantage of the view, however, is that anti-risk epistemology fares much better than anti-luck epistemology when it comes to accounting for the phenomenon of negative epistemic dependence. In particular, anti-risk epistemology is ideally placed to explain why such epistemic dependence is incompatible with knowledge, even when the negative epistemic dependence in play is of a purely modal variety. (shrink)

Does Augustine put his finger on time? -- Time for history -- Determination -- Self-determination -- Time, knowledge and truth.

I reject three theories of practical reason according to which a rational agent's ultimate reasons for acting must be unchanging: that one is rationally obliged in each choice (1) to be prudent--to advance all the desires one foresees ever having (the self-interest theory), rather than just those one has at the time of choice, or (2) to cause states of affairs that are good by some timeless, impersonal measure (Thomas Nagel), or (3) to obey permanent, universalizable deontic principles (Kant). Whether (...) a rational agent's reasons consist in her desires, in the goodness of certain states, or in deontic principles, her reasons now can ask her to take different, conflicting things as reasons later; and contradiction results of rationally obliging her not to take the new things for reasons. (shrink)